|
|
|
Synchroslice
- the complete and
integrated laboratory for high throughput drug screening
Model SS Series |
|
- 4 & 8 Channel Systems
for neuropharmacology and toxicology
|
|
Acute vital tissue sections like the
hippocampal slice preparation have become a valuable tool in
neuropharmacology and toxicology for evaluation of drug effects in
the pharmaceutical industry. However, with a single standard
experimental setup only a few tissue slices can be characterized
within one day. A higher throughput of tissue sections, different
drugs or concentrations is difficult and time consuming.
With the new SYNCHROSLICE system
Lohmann Research Equipment overcomes this problem by
electrophysiological evaluation in up to 8 tissue slices
simultaneously. Single dose-response response curves can be examined
with a single loading of 8 slices in an interface or submerged
chamber. Sections can be electrically stimulated and extracellular
somatic and dendritic field potentials are recorded simulatenously
with eight 2-fold microelectrodes. Various stimulation protocols
like single pulse, double pulse, HFS, LFS or theta stimulation (for
LTP/LTD experiments) are possible.
|
 |
|
|
Electrode positions are visualized with an
8-fold CCD camera system. Drugs are applied via a 8-fold valve system
including a multichannel peristaltic pump.
The SYNCHROSLICE software
controls the complete experiment including stimulation, drug
application, data acquisition and on-and offline analysis. Signal
parameters like peak amplitudes, slopes, latencies, area under curves,
etc. are determined online and displayed during the experiment.
Routine viability checks guarantee a continous control of tissue
healthyness. Cutoff criteria can be set by the customer to stop
recordings from non viable slices. All parameters, settings,
experimental and tissue identifications or acquired data are stored on
HD. Export functions allow a transfer of data into conventional
spreadsheet and analysis programs.
The SYNCHROSLICE drug effect
explorer was originally designed for the classical
hippocampal slice preparation. However, other tissue slices from
neocortex or other structures in the brain and even acute heart slices
can be evaluated.
|
|
|
Synchroslice
Features: |
- Multiple slice chambers
- Interface or submerged type
- Precise temperature control
- 2-Ch. headstages, i.r.>1GOhm
- Filter amp, fixed bandwidth 0.1-3KHz
- Two fold recording electrodes
- Bipolar stimulation electrodes
- Ergonomic work platform
- Antivibration table
- Controlled gas regulation
- Peristaltic pump with digital control
- Valve switches for test solutions
- Online stimulator
- 4-Ch. inspection cameras & quad display
|
|
Synchroslice is a product of
Lohmann Research Equipment
 |
- Drug effect explorer software
- 16-Ch. USB data acquisition
- Control: stimulation, drug application, data
acquisition, on & off line analysis
- Monitor: peak amplitudes, slope latencies, area
under curves, tissue health
- Continuous control of tissue slice health inc cut
off criteria
- Set up and three-day training included
|
|
|
View our other Slice Systems
Information:
|
|
